ABSTRACT
Background: We present the case of a 55-year-old woman, admitted to the Infectious Disease Department of Policlinico Umberto I, Rome, in mid-March 2020, with suspicion of COVID-19 infection. Objective(s): The rRT-PCR was negative, and the following CT scan, performed to exclude false-neg-ative results and help diagnosis, was inconclusive. Method(s): It was decided to submit the patient to a 99mTc-HMPAO-labelled leukocyte scan. Result(s): This exam led to the diagnosis of infective endocarditis. Conclusion(s): In the present pandemic scenario, 99mTc-HMPAO-labelled leukocyte scan represents a reliable imaging technique for differential diagnosis with COVID-19 in patients with confusing clinical signs, possible false-negative rRT-PCR results, and inconclusive CT scan.Copyright © 2021 Bentham Science Publishers.